DEA offices in Missouri enforce federal controlled substance laws, investigate drug trafficking networks, and regulate the legal distribution and use of controlled substances by healthcare practitioners within the state. DEA activities in Missouri are coordinated through the regional field division that covers the state.

Healthcare practitioners and pharmacies in Missouri who handle controlled substances must maintain an active DEA registration and comply with federal scheduling and recordkeeping requirements enforced by the DEA's Diversion Control Division.

Medical practitioners in Missouri who need to register or renew a DEA controlled substance registration should do so through the DEA Diversion Control Division's online portal. To report suspected drug trafficking or controlled substance diversion in Missouri, contact the nearest DEA field office or submit a tip at the DEA's official website.